Blockade of Opioid Receptors Located in the Rat Nucleus Cuneiformis Reduced the Antinociceptive Responses of Local But not Systemic Administration of Morphine in Formalin Test
نویسندگان
چکیده
Morphine, Naloxone, Formalin Test,
منابع مشابه
Blockade of Opioid Receptors Located in the Rat Nucleus Cuneiformis Reduced the Antinociceptive Responses of Local But not Systemic Administration of Morphine in Formalin Test
ABSTRACTPrevious studies have shown the role of opioid receptors located in the nucleus cuneiformis (CnF) in acute pain, but not in chronic pain models. In the present study, we have determined that possible effects of these receptors at the CnF on both early and late phases of formalin test following local and systemic morphine administration. Each rat was given a subcutaneous 50-μl injection ...
متن کاملContribution of the Nucleus Cuneiformis to the Antinociceptive Effects of Systemic Morphine on Inflammatory Pain in Rats
Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats. Methods: A total of 201 male Wistar rats weighing 260-310 g were used in...
متن کاملA Study on the Effect of Intracuneiformis Nucleus Microinjection of GABAA Receptor Agonist and Antagonist on Antinociceptive Effects of Morphine by Formalin Test in Rat
In the present study, the effects of intracuneiformis nucleus microinjection of gamma-aminobutyric acidA (GABAA) receptor agonist and antagonist on antinociception inducced by morphine were investigated with formalin test in rat. Intracuneiformis nucleus microinjection of morphine (10µgr/rat) and Bicuculline (50, 100 ng/rat) induced antinociception in the both first and second phases of formali...
متن کاملAnalgesic effect of morphine microinjected into the nucleus raphe magnus after electrolytic lesion of nucleus cuneiformis in tail-flick and formalin tests in rat
Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...
متن کاملاثر تزریق آگونیست و آنتاگونیست گابا B به درون هسته میخی شکل بر اثرات ضد دردی مرفین در موشهای صحرایی نر
Effect of GABAB Agonist and Antagonist Microinjection into Cuneiformis Nucleus (CNF) on Morphine Induced Antinociception by Formalin Test in Rat M. RezvanipourPhD , V. Sheibani PhD , M. Bakhshesh MSc Received: 21/05/06 Sent for Revision: 25/06/06 Received Revised Manuscript: 11/12/06 Accepted: 27/01/07 Background and Objective: There are several evidences that show cuneiformis nucleus is involv...
متن کامل